Ok, it sounds like you need to start with a fresh install of PB and or HB. Also make sure that you are running wow directly and not from the launcher. Try those things and let me know if that fixes it!
Reinstalled HB on the computer. still the same problem :/ can't get it running
Starting the bot!
Changing current profile to level 0 - 2147483647
System.IO.DirectoryNotFoundException: Could not find a part of the path 'C:\Users\Lundmark\Desktop\HB\Bots\ProfessionBuddy\Localization\Strings.xml'.
at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
at System.IO.FileStream.Init(String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFrom*****, Boolean useLongPath)
at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess access, FileShare share, Int32 bufferSize)
at System.Xml.XmlDownloadManager.GetStream(Uri uri, ICredentials credentials, IWeb***** *****, RequestCachePolicy cachePolicy)
at System.Xml.XmlUrlResolver.GetEntity(Uri absoluteUri, String role, Type ofObjectToReturn)
at System.Xml.XmlReaderSettings.CreateReader(String inputUri, XmlParserContext inputContext)
at System.Xml.XmlReader.Create(String inputUri, XmlReaderSettings settings, XmlParserContext inputContext)
at System.Xml.Linq.XElement.Load(String uri, LoadOptions options)
at System.Xml.Linq.XElement.Load(String uri)
at HighVoltz.Professionbuddy.LoadStringsFromXml(String path) in c:\Users\Lundmark\Desktop\HB\Bots\ProfessionBuddy\Professionbuddy\ProfessionBuddy.cs:line 579
at HighVoltz.Professionbuddy.LoadStrings() in c:\Users\Lundmark\Desktop\HB\Bots\ProfessionBuddy\Professionbuddy\ProfessionBuddy.cs:line 557
at HighVoltz.Professionbuddy.Init() in c:\Users\Lundmark\Desktop\HB\Bots\ProfessionBuddy\Professionbuddy\ProfessionBuddy.cs:line 516
PB 1.540: Adding TradeSkill First Aid
PB 1.540: Adding TradeSkill Mining
PB 1.540: Done Loading Tradeskills.
Object reference not set to an instance of an object.
Bot Stopped! Reason: Object reference not set to an instance of an object.
Nevermind I got it working now

Thans for help, I had to reinstall my ProfessionBuddy, guess it was broken in some way