I use PQR simply because I find it to be less resource intensive than HB if I'm playing the character and gives me a little more control. Sometimes if you need to stop HB when you have 4-5 instances of it open, it will cause the window to lock up and you have to restart each window. With PQR, it's just one less thing I need to micro manage.
If you use Lazyboxer exclusively, there may be times that you find you've ran off and your followers are now 50 yards behind you and they don't sync up to the leader until you start combat or interact with an NPC. The follow macro simply eliminates lost dps and keeps the followers close.
Along with the following, Keyclone also allows you to setup your wow windows exactly how you want them and puts the appropriate wow accounts into each window and lets me log in to all 5 accounts in about a quarter the time as it would take me otherwise.. I play the main character on a 1600p screen, and use a second 1200p monitor for the 4 followers, the HB windows and PQR window. The windows are all set up without borders and looks pretty impressive. I'll take a pic one of these days and post it here so you can see exactly what I'm talking about.