Although i have used questing (Kicks) and grind (Botanist) profiles and they are both very good, i would say questing is faster if you can monitor the bot frequently. If you want, for example, all night botting with no supervision, then grind is your choice.
Usually, i quest during the day while at work and supervise the bot with a remote connection to my home desktop. During the night i go to bed and leave the toon grinding (Botanist profiles work without issues).