My general settings for db is set at:
Ignore Goblins, Elite combat at 25, min trash mob size 8, cluster radius 25. uncheck extend trash kill range after combat. check ignore elites and all others on that tab, loot rules, I use trinity hard rules(granted I did edit the file to do some boost on requirements).
set legs for salvage, pick up gold at 2k or over. leg plans, infernal keys, and craft materials(demonic essense) and I do pick up Mythic healths. I don't pick up gems, tomes, reg plans..
If you can pick up a gear piece with any pickup radius, that's a bonus for survival and time spent on runs.
under objects: ignore shrines, skip destructables unless stuck, open cont rage is 10, destructable attack range is 1.
Combat settings for my barb are simple, I don't use fury dump always or fury dump in wotb mode. arcane, desecrator, molten core, and poison tree are all max on radius and health. that way he stays far enough away from them instead of trying to run through them for something.
These might not be the best rules ever, but picking up every little thing will take too damn long, ruining your xp/hr, leg/hr, and so forth. I pick up about 2-3 legs hr on mp10 and get about 50-60 mill xp/hr(but i'm undergeared still) on mp10. it's doable for me, works for me and i'm not complaining. Gear I have is what I could afford closest to the org posts suggestions.