ok for those that have mass number of deaths. there are issues that happen like the loot chest glitch... which is a simple check. But as for the rest like the priest above. In helping people who've pm'd me ... remember that unless you know for sure how a CC works with a particular profile you should check it every so often the first couple times you run a profile. This in mind, i would HIGHLY recommend checking for new gear in the AH every 10 levels. (10, 20, 30, .....) This is due to once you hit 15 to 20 range, basic white/grey gear becomes a crutch. When getting gear, if you have gold flow problems i would say look at the weapon area for melee classes first.. and for spellers.. wearable gear.
Again, remember, unless you know how a profile and a CC work even 80% you should never assume it will always have the best results for you. After you run it a few times, you'll know where the quirks are and adjust things accordingly.. This will allow you to let it run longer without supervision.
Another tip, its mentioned in a few places, use lootfilter. I use it both botted and non-botted accounts. My own personal preference is to have it delete greys (if your short on gold some prefer to sell greys). But deleteing them allows for longer runs without requiring vendor runs.