Fair enough. Perhaps, instead of creating a single 1-80 profile, it would require multiple, smaller profiles that would require you to position the bot somewhere before kicking it off. That's not too dissimilar from what you currently have, ya know? Just break down the guide into bite-sized chunks, listing a start and finish point. Also, once it completed the last quest, it would just grind the area awaiting you to stop, change profiles, and reposition the bot.
To address some earlier points - Sure, some things that Zygor's lists in the guide are impossible for the bot to do, in its current incarnation, but the real question is: Why do we care? Yes, it won't be completely autonomous from 1-80, but what profile is? You may just have to intervene more often (negligible) but I think the results (i.e. speed of questing) would make it more than a worthwhile sacrifice. When I have time, I'm going to dig up Zygor's guide (if I can find it) and look into some of the better profiles, to see if I can bring the two together, without stepping on anyone's toes.