OK profile is pretty much ready for some alpha testing. I ran it through MP3 on my monk and had no problems whacking the ubers on the first try. Will attempt MP4 tomorrow.
If you want to use these files, READ ALL OF THIS BELOW!
This is not an official release yet as I have a few things to finish up, but if any of you are curious as to how your char will perform, give it a whirl. Only do this while monitoring your bot. Once you run out of machines, it will keep looping the profile right now. You also have to craft infernal machines on your own at this point. So craft a few (or a bunch), just make sure you have enough to do all 3 ubers...if you only have 2 and try to run it from the beginning, it will likely get stuck in heretic's abode or just reset itself once it uses all the machines up.
I had some built in handling to stop the bot if you had less than 3, but of course if you raise all 3 portals and happen to die on the last uber set, it'd think you didn't have enough machines and quit...so for now I disabled it until I fix it tomorrow.
The bot will always check your stash after each Uber kill (and right before attempting the first uber) and move machines if necessary from your stash to backpack. This is because a town run in the middle of killing ubers is possible/likely and will end up stashing your infernal keys. It's a quick check so not a big deal, and sure beats forcing you to put the machines in a protected slot.
Lastly, YOU MUST USE MY UberRun PLUGIN & ATTACHED TRINITY FILE FOR THIS!
It's based off unified version v.35 at the moment (I will update to latest eventually, but I need them to put my Uber stuff in their version when I'm done)
It is required to use this trinity file because Trinity has no detection for Ghom's gas clouds or Zolton's Time Bubble/Twisters. If you want to die quick, don't use my file

I plan on putting in some AoE sliders for Ghom's gas clouds...for now I set it to 0.55 health before it attempts to get out. Sorry if that doesn't work for you initially, you'll get your slider soon enough for your class. I also had to mess with Priorities and Boss assignments. Trinity isn't sure what to do with two bosses. I removed Siegebreaker as a boss because it would constantly go after him first. Your char will still go after him first, but should make his way over to Zolton quickly.
I do need to set some kill radius numbers for these guys because I think unified version reduced radius of elites from 60 to 30...and Zolton especially tends to warp out past 30 frequently. So you may find yourself jumping back and forth. I will get this fixed so it focuses on Zolton as much as possible. The others seemed to work decent for me, though i will probably have to do the same thing. I will refine tomorrow so it fights better.
Again, this is an alpha test. See what your bot can do against the ubers. I'm pretty confident I can beat them on MP4 as is. With some further combat tweaking, who knows. MP5 maybe. I typically bot at MP4 so I would say whatever you bot at, you should be able to do the ubers too assuming you don't die frequently at your MP level (I don't at MP4)
Look for an official BETA release tomorrow. It won't craft machines, but should be afk-able after you've created your machines.
Oh, and I haven't had an organ drop yet and it might not pick one up

I added an organ internal name and made it appear like a Key for now...but there may be more than one name (key's have 2 names, I imagine something similar might be for organs). If you get lucky and have an organ drop, please let me know if it picks up. If it doesn't please pause the bot, dump the RActors, and let me know what it says so I can get it into Trinity. Best of luck!