I, just like Glendrum, have gotten 5 accounts banned. My main account has never been banned/suspended, and I have never logged into the bot on my main account.
The devs seem to now have a good grasp on Trion's detection schemes, whereas before the previous 2 banwaves, they did not. There has been a lot of news about Trion's anti-cheat schemes recently, which is good for bot developers. If the devs continue to stay on top of detection schemes and Trion doesn't make major changes to their detection, we should be good to bot. The game is new though and hasn't had the years and years of reverse engineering that games like wow has, so it's always possible that something could be slipped in somewhere that noone has found yet.
The golden rule of botting always has been and always will be:
If you're afraid of losing your account, don't bot.