Download the profile, place it in your HB folder, start bot > load profile>navigate to the profile you just put in the HB folder > slect what bot you are using from the drop down menu such as Gatherbuddy 2. Hit start
you need to pay attention to what profiles you are using.
Ore, rares, herbs etc.. are Gatherbuddy 2 bot most will be in the Gatherbuddy section and marked as [GB2]
Leveling profiles such as kicks, Cavs 1-90 are for use with the Questing bot.
Fishing profiles found in the forum are for use with Auto angler bot.(Seperate bot download, not included with HB download but its just a click away from getting)
and the list goes on, take your time and read around the forums. It may seem like a shit load of confusing info at first, but one you understand the basics. Everything else just falls into place.