Jesus you kids bitch a lot. First off, the profiles probably need to be updated for 1.49, so if you don't know how to do that yourself, then you need to wait for Carguy, Zoinx, or whomever's profile you use to update it. Also, if you read the patch notes for 1.49, I'm pretty sure it says something in there, like "Bot should now once again, click any error notifications that get's in the way."
So, you are asking how to get your bot to work, and don't include a single log. You include nothing to help us troubleshoot your issue, other than attitude, and a poor one at that. How about you read some posts around here about asking for help to get your bot up and going, and you'll realize that we enjoy logs, not "OMG WTF DB, my bots not run, OMG YOU SO BROKE!"
That being said, how about do what they asked, disable all plugins, and see what happens then. Or go learn C#, use the tags, and create your own profiles, that way you can keep them updated!