Honestly these arent the greatest of answers. In reality ryftobuddy is right in saying that its as safe as botting anything else, meaning anyone can report you at anytime. At anytime Blizzard can flag accounts based on their insights. Botting is risk. That being said using the 95-100 profile is relatively safe compared to other profiles where people are vigilant about reporting (BGBuddy, DBuddy). I ave ran 95-100 several times with zero incident. But you MUST monitor you bots. I ran three bots simultaneously recently and noticed that 1 out of the 3 would always become "broken" at some point. Either running repeatedly into elite mobs, pathing back and forth in a short area, and so forth.
Know the risk, accept the risk, and mitigate it as best you can. That's all you can do.