It depends how much CPU power you have. Depending on that you might start getting freezes and that may actually cause ExileBuddy to crash.
but still it's not possible to minimize the game? (down to the taskbar)
you can really trim down the gpu use of it by changing settings, but the CPU will still be high. I can play some not CPU intensive games, LOL, diablo3 etc but depends on comp.So that´s why my bot craps itself lol
I mostly play csgo / league / hearthstone sometimes skyrim. I have a 3770k and 8gb of ram. sometimes there is tiny bits of lag but it only happens every so often. Never had issue with the bot bugging or stopping or anything wh ile playing.