I was having it but it was a blacklisting issue that I think get fixed in the last update from trinity, and the 4.0.1 and 4.0.2 versions of fallendev's profile.
if you use yar, please check your jumpstart file contains this:
<!--Black Listing Actors-->
<TargetBlacklists>
<!--Agony 2 & 3-->
<TargetBlacklist actorId="79421" />
<TargetBlacklist actorId="177439" />
<TargetBlacklist actorId="167185" />
<TargetBlacklist actorId="102927" />
<TargetBlacklist actorId="144149" />
<TargetBlacklist actorId="92387" />
<TargetBlacklist actorId="104545" />
<TargetBlacklist actorId="108266" />
<TargetBlacklist actorId="86624" />
<TargetBlacklist actorId="109209" />
<TargetBlacklist actorId="5723" />
<TargetBlacklist actorId="156058" />
<TargetBlacklist actorId="90419" />
<TargetBlacklist actorId="105321" />
<TargetBlacklist actorId="102711" />
<TargetBlacklist actorId="105323" />
<TargetBlacklist actorId="58568" />
<TargetBlacklist actorId="3949" />
<TargetBlacklist actorId="5717" />
<TargetBlacklist actorId="58568" />
<TargetBlacklist actorId="5740" />
<TargetBlacklist actorId="158944" />
<TargetBlacklist actorId="167311" />
<TargetBlacklist actorId="89579" />
<TargetBlacklist actorId="89578" />
<TargetBlacklist actorId="170913" />
<TargetBlacklist actorId="5895" />
<TargetBlacklist actorId="5896" />
<TargetBlacklist actorId="5898" />
<TargetBlacklist actorId="5900" />
<TargetBlacklist actorId="116752" />
<TargetBlacklist actorId="108882" />
<TargetBlacklist actorId="206461" />
<TargetBlacklist actorId="105361" />
<TargetBlacklist actorId="168875" />
<!--Highlands, Weeping, Misery-->
<TargetBlacklist actorId="5482" />
</TargetBlacklists>
If it does not, add it from the next line of where gameparams, questid etc is set.
In order to be completely sure it won't happen again, you'll have to add it in EVERY .XML FILE of the profile, because it seems your blacklist is not updating, as in, only the first profile loaded blacklist will work, so, whenever you experience a crash that closes Db, it will reload last profile used (as an example, Weeping.xml if you were in weeping hollow when db crashed) and since weeping itself has no blacklist, you could be facing the same issues onwards.
I hope I made it clear, it's clear in my mind but translating to english is a different thing