Depends on what you are bottling, of course. If you are bottling moonshine for example, 24/7 would probably result in accidental overdoes on alcohol fumes, which, tbh, is pretty bad for your health. Not to mention, that when drunk on fumes, you won't be able to set up your bots that good xD
I mean, save for the case where you are actually a nasty hillbilly.. they seem to be immune to moonshine fumes, at least in my experience.