When just starting a human character (The one race I prefer to bot) buy it a good white weapon or Goldtooth might become a problem.
Entering Westfall there is a quest in the beginning where it looks for clues, do that manually as well, will save a buttload of time in the 12- 58 profiles current state.
Do the very last bit in Westfall manually too, the whole flying back and forth from Stormwind, in my experience it can never figure that out and starts to run instead,huge time sink.
Redridge, do the first part of the Bravo Company key quest manually, can save a lot of death runs.
In Duskwood at the end, when you need to return the ring to grave, do it yourself, otherwise the bot will spend too much time grinding mobs.
Usually you'll need a bit of exp before it can start Northern Stranglethorn at level 27, the profile grinds this out.
I have two approaches to this, if I have 1'ish bar left I let it grind, if more, I do a dungeon.
Stranglethorn, both north and south, have very few issues in my cases. It might accidently fall in the water in Booty Bay and get stuck, just nudge it out of there.
North may have an issue when killing the Goblins for the 5 crystals, if it starts to go in the big building it most likely will die a few times, this is not the profile, but the bot doing wierd targetting.
It will target the nearest, which might be in a room above, then proceed to run all the way up the mob, pulling everything in its way.
Western Plaguelands, I do Andorhal manually, all of it. The bot can do it, but it will take a lot of time doing so. Otherwise I have had no issues there.
Eastern Plaguelands is pretty flawless. I do two areas manually to save time, The Noxious Glade and Zul'Mashar.
Badlands is no problems, atleast for me. I hardly ever notice the bot is there.
Searing Gorge is the same as above, I have no problems running it. It might die a few times due to odd targetting.
I only do the first part of Burning Steppes, which works just peachy. When hitting 50 I start all over with a new bot.