1) a 1-80 Profile no matter how carefully meshed would still really be too big to load all at once.
2) Zoning isn't a problem for HB atm; But it can't portal or use boat paths (Both possible with addons, One to reach destination and click, and One to reach destination > Wait for mob yell > walk forward 25yards > wait for new zone > Wait for mob yell > 180 turn move 25yards > continue profile )
3) Running a 1-60 then a 58 - 70 and a 68 - 80 Is more effective, easier to bug fix/alter
4) Why don't you look around the forums on creating your own mesh and profile, there are guides out and its pretty easy.