The risk of a ban is always there. I've run QuestingBot with Kick's profiles overnight several times myself, often waking up to the bot being offline for several hours because of a bug or being stuck or something similar, or even worse when it's standing at the same questgiver for hours trying to pick up a quest or something similar. Never been banned, but I do know I'm taking a risk.
If you're afraid of being banned, only bot while supervising. No bot/profile is 110% perfect, but most of them are quite close in my experience. It's all about the risks you're willing to take.