Use Kick's profiles and follow every step of the instructions.
That said, profiles aren't 100% perfect, and neither is HB so sometimes either one or the other can bug out.
Other than the plugins Kick recommends, I suggest you get:
*Auto Precision
*CombatHelper
*StuckHelper
Those implement general stability fixes that will help greatly while questing.
Kick has been working on his profiles a lot the past week, and there's very few bugs. If you happen to catch one
10 mins after you go to bed (like it happened to me last night), you're screwed, but most of the time it works well enough.
Just don't expect 100% AFK 1-85 because it's likely to never happen, but if you're patient, you won't have to do anything.
My best mark has been 4 days to 80 with HB (give or take an hour).